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(September 2016)

As with other agents in the incretin receptor agonist class, the most frequently reported side effects of retatrutide in the Phase 2 clinical trial were gastrointestinal in nature

A study demonstrated that GLP-1, via cAMP-systems mediated by astrocytes, inhibits the expression of IL-1beta, an inflammatory molecule that is highly implicated in cell death, brain injury, and neurodegeneration [58]