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Ultrastructural studies have revealed an increase in the size and number of mature melanosomes in basal keratinocytes and dermal melanophages, suggesting a functional alteration in melanocytes that leads to increased production and transport of melanosomes

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PMID: 40879372 Curr Issues Mol Biol Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability

The implication is that GLP-1 receptor activation may partially normalize dopamine signaling in metabolically dysregulated brains