It extends the anagen phase, keeping more follicles in active growth simultaneously
reported in their study that ellagic acid evaded MDR more efficiently than 3,4-Dihydroisocoumarins in drug-resistant cancer cell lines such as HCT-15 (that increases the expression of P-gp), and MCF-7/MX (that raises the expression of BCRP), respectively, at much lower doses than the iso-coumarin derivative [215]
Uma Mahesh B, Shrivastava S, Kuncha M, Sahu BD, Swamy CV, Pragada RR,
Firstly, resveratrol decreases the expression of genes that are responsible for encoding the drug-metabolizing enzymes and drug transporters like ABC efflux transporters and proteins like MRP1/ABCC1 that contribute to the elimination of cancer drugs and chemoresistance [220, 221]