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The pipeline also includes triple agonists like retatrutide, which targets GIP, GLP-1, and glucagon receptors and produced 24.2% weight loss at 12 mg in a 48-week phase 2 trial

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The use of lactate for energy has been proposed to occur within the mitochondria where it can be oxidized to pyruvate by mitochondrial LDH which localizes to the inner mitochondrial membrane