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Overproduction of free radicals, depletion of ATP content, induction of nuclear fragmentation, overexpression of death ligand tumor necrosis factor-alpha and activation of cJun NH2terminal protein kinase (Ng et al., 2006

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However, muscle uptake of carnitine from the blood is a long process and is not highly sensitive to additional carnitine uptake [271], indicating that muscle cells have a certain degree of saturation of carnitine uptake and that additional intake has a limited effect on muscle carnitine levels when the energy demand is low or when the metabolic status is stable