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(2022) demonstrated that NAC treatment significantly increased the number and duration of spike-wave discharges in WAG/Rij rats (rat model of absence epilepsy), exacerbating absence epilepsy while ameliorating neuropsychiatric comorbidities

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"Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface"

Human trials are what actually matter for clinical decisions