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doi: 10.1016/j.redox.2023.102690 191 TanQ.MaX.YangB.LiuY.XieY.WangX.et al

It was engineered isolate hGHs lipolytic (fat-breaking) properties without activating the growth hormone receptor or increasing IGF-1. The design allows it to mimic hGHs metabolic domain in a shorter, more stable form

Tirzepatide acts on both GIP and GLP-1 receptors, while semaglutide acts only on GLP-1 receptors, leading to somewhat different effects

In summary, future clinical trials should prioritize enrolling individuals at risk, followed by those in the early stages of the disease, as this offers a higher likelihood of demonstrating neuroprotective and disease-modifying effects