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Interestingly, the combined therapy of PYY3-36 and GLP-1 receptor agonist (exendin-4) was found to decrease food intake and body weight in an additive manner in animal models and humans

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Concerns have been raised regarding the potential for abnormal cell growth, particularly in the absence of long-term safety data from clinical research

In turn, this mechanistic effect might contribute to an environment that favors enhanced nutrient and oxygen delivery through vascularization, complementing the peptides other reported influences on cell survival and proliferation