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Since their initial approval in the early 2000 s, the pharmacotherapy of GLP-1 RAs has been well recognized not only for achieving glycemic targets but also for their effectiveness in promoting satiety and weight loss, as well as their association with reductions in cardiovascular risk and all-cause mortality

Side effects are minimal and may include mild fatigue or redness at the injection site

Researchers examining potential neurological or cognitive effects often prefer the nasal route because it provides more direct access to the central nervous system

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