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MPH can lead to induced oxidative stress [49,50] by increasing reactive nitrogen and oxygen species that can alter antioxidant defense mechanisms, potentially involving enzymes, which consequently links to lipid, protein, and DNA damage [50,51,52] MPH can cause oxidative damage in the prefrontal cortex by promoting the auto-oxidation of catecholamines, such as dopamine and norepinephrine

Such non-native disulphide bonds are now known to form in proteins under normal physiological conditions (Jansens et al , 2002)

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It is prohibited at all times in an out of competition and is not eligible for the therapeutic use exemption because it has no approved therapeutic uses