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Semaglutide imitates the glucagon-like peptide-1 also known as GLP-1 hormone, a chemical that affects the parts of the brain that control hunger and food intake

however, individuals already taking glucose-lowering medicines (including insulin) may be at increased risk of hypoglycaemia if GH-mediated effects alter their insulin sensitivity Injection site reactions, including pain, redness, and infection risk For retatrutide , the side effect profile observed in clinical trials is consistent with that of other GLP-1 receptor agonists and includes nausea, vomiting, diarrhoea, and constipation

Sifuentes-Franco S, Snchez-Macas DC, Carrillo-Ibarra S, Rivera-Valds JJ, Zuiga LY, Snchez-Lpez VA

is supported by US National Institutes of Health (NIH) grants R01-DK55758, P01-DK088761, R01-DK099110 and P01-AG051459 and by an unrestricted grant from the Novo Nordisk Research Foundation