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The Funds are open-ended sub-funds of the First Trust Global Funds ICAV (the "ICAV") (formerly First Trust Global Funds plc), an umbrella UCITS fund with segregated liability between sub-funds, established as an Irish collective asset-management vehicle with variable capital and limited liability under the laws of Ireland with UCITS registered number C99076

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Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery