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Retatrutide is an investigational once-weekly injectable triple receptor agonist developed by Eli Lilly, designed to simultaneously activate GLP-1, GIP, and glucagon receptors to reduce body weight and improve glycaemic control
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This creates a cascade of metabolic dysfunction that makes traditional weight management approaches less effective during perimenopause.[2] GLP-1 Receptor Agonists: Mechanisms of Action in Perimenopause GLP-1 receptor agonists work through multiple pathways that are particularly relevant to perimenopausal women: Appetite Regulation and Satiety These medications reduce appetite and food cravings by activating satiety centers in the brain and slowing gastric emptying
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