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Vitamin B12 injection safety B12 injections are generally well-tolerated, but possible side effects include: Pain or redness at the injection site Mild diarrhea or upset stomach Itching or rash (rare) In rare cases, individuals may experience an allergic reaction to B12 injections

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This is not a complete list and there are many others. The warning relates to both the unproven effects of these products, but also the risk of infection from possible non-sterile products being injected