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Cells manage ROS through antioxidant enzymes, such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD), and non-enzymatic molecules like melatonin, ascorbic acid, and tocopherol
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However, under a tumorous environment, elevated expression of lysosome protease B can enzymolyze the two amide bonds of the link and cause cytotoxins to release in the complete active form