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Massafra et al (21, 22) reported that a significant positive correlation existed between physiological estrogen and antioxidant expression during the menstrual cycle, but no significant changes occurred in catalase

Figure 4 Concurrently, the ATP deficiency resulting from hypoxia promotes the disintegration of organelles and cell membranes, producing substantial amounts of oxygen free radicals and inflammatory mediators, which further intensify cellular damage and apoptosis (80)

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