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2016 Oct;17(10):970-6

Women had to have at least seven moderate to severe hot flashes a day to be in the study and they used a mild, moderate and severe grading of hot flashes

Bacterial toxins and other pyrogens stimulate the production of cytokines by leukocytes, and these cytokines increase prostaglandin synthesis in the preoptic area of the hypothalamus

Vague labeling like "copper peptide complex" without percentages is a red flag