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In sex-specific analysis of CVD events, we used individual-level data from UK Biobank

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competitive tyrosinase substrate that redirects melanin synthesis toward lighter pheomelanin Niacinamide (Vitamin B3) Inhibits melanosome transfer from melanocytes to keratinocytes (the key step producing visible pigmentation)

There is also a patent (US20020183255A1) specifically covering the use of KPV for dermatological disorders, including eczematous dermatitis