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Cardioprotective actions include the inhibition of TLR4/NF- B/NLRP3 signaling, reduction of cytokine levels (such as IL-6 and IL- 1), and prevention of myocardial remodeling and dysfunction

Sample collection This study was approved by the Institutional Bioethics Committee of Eulji University (EMC 2016-08-009-010, October 10, 2016), and written informed consent was obtained from the participants

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Yang WS, Stockwell BR (2008) Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells