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Symptoms of melanoma may include: Related Stories Men face higher risk of late-stage cancer diagnoses than women New BRAF protein conformation opens avenues for cancer treatment Tailored drug combinations improve outcomes for treatment-resistant advanced melanoma fatigue weight loss loss of appetite difficulty breathing bone pain headaches seizures swelling of the liver Tests used to diagnose metastatic melanoma include: biopsy blood tests chest x-ray ultrasound CT scan MRI positron emission tomography (PET) scanning Treatments Metastatic melanoma may be treated as follows: Surgery - Surgical removal of the lesion, when possible, is often recommended, especially when there is a solitary metastasis of the skin in subcutaneous tissue or a lymph node