Indications and Usage for B-12 Compliance Injection Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see DRUG INTERACTION), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
This recommendation remains the same during pregnancy and breastfeeding, though ensuring adequate intake is particularly important for vegans during these periods
However, this protein was shown to undergo a temperature-induced transition to a more disordered state with the emission peak shifted to 353 nm (Timm et al., 1992)
GLOW patients with severe deficiency may start with weekly injections, tapering to monthly maintenance
