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Age and Genetic Factors : As people age, their bodies naturally produce less intrinsic factor, reducing the ability to absorb B12 from food and supplements

Metzendorf NG, Godec A, Petrovic A et al (2025) Somatostatin therapy, neprilysin activation, and amyloid beta reduction: a novel approach for Alzheimers treatment

Individuals with Gastrointestinal Disorders Conditions such as Crohns disease, celiac disease, or those who have undergone weight loss surgery can affect the bodys ability to absorb B12

Anyone interested in using these medications should ask about the manufacturer and compare their choices with FDA-cleared products, which usually have more data on safety and use