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International sports authorities (WADA / USADA) These compounds are treated as prohibited in sport

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In nonadipose tissues, such as skeletal muscle, HSL is activated by phosphorylation in response to epinephrine (-adrenergic receptormediated activation of PKA) and muscle contraction (calcium release from sarcoplasmic reticulum)

GIP adds an anatomically distinct perturbation: it increases splanchnic blood flow, expanding the mesenteric capacitance bed and reducing effective venous return to the right heart (Hedge et al., 2025)