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This doesnt necessarily make the medication dangerous in a one-time scenario, but it significantly increases the likelihood of severe gastrointestinal distress

NA might have more NAD + activity in tissues with higher amounts of enzymes used in the Preiss-Handler pathway (e.g., small intestines, kidneys).[65,66] NAM and the salvage pathway might be the preferred means for NAD + replenishment in many peripheral tissues, including the brain and skeletal muscle, where its enzymes have higher expression.[38,67]

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