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Human studies have not determined which approach is superior

When changing any transdermal patch, patients should remove the old patch carefully, fold it in half with the adhesive sides together, and dispose of it safely according to the medication guidetypically in a sealed container out of reach of children and pets

Another investigation showed cold air therapy and ice massage resulted in immediate pain relief lasting at least 60 minutes, with temporary improvements in handgrip strength

Acknowledgments Special appreciation goes to Meiying Jin for her essential input on the research ideas and her financial support for this paper