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Its function as an antioxidant and determinant of cellular redox potential is crucial both for protection from reactive oxygen species as well as a signaling molecule involved in cellular proliferation, cell cycle regulation, and apoptosis

This dual approach could be particularly beneficial for patients who have struggled to achieve their weight loss and glycemic targets with traditional therapies alone

Invest 131, e140695

Three weeks of moderate-intensity aerobic exercise significantly increased myocardial FNDC5 expression and upregulated serum Irisin expression in irradiated X-ray-induced radiation-induced heart disease (RIHD) mice, significantly upregulated myocardial Drp1, PINK1, and LC3B expression in RIHD mice, promoted mitochondrial fission and mitophagy, and consequently increased mitochondrial protein and ATP content, decreased myocardial inflammatory cytokines infiltration and myocardial fibrosis area, upregulated LVEF, left ventricular end-diastolic dimension (LVEDD), and systolic left ventricular dimension (SLVD), and increased RIHD mice body weight, grip strength and aerobic fitness