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The 'C' originally referred to choline but is now used interchangeably to mean the combined formula

A recent study in ATC cells showed that metformin increased NIS mRNA and protein expression (as well as mRNA of thyroglobulin, TSHR, and NKX2.1) acting also as a demethylating agent ( Finally, some studies also showed that metformin could synergize with other drugs increasing their anti-cancer effects

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MOTS-c (pronounced mots-see) stands for "Mitochondrial Open Reading Frame of the 12S rRNA-c." Its a 16-amino acid peptide encoded by mitochondrial DNAmaking it part of a novel class of mitochondrial-derived peptides (MDPs)