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Notably, coculture with L-Cn resulted in significantly reduced frequencies of IgG-secreting B cells and a tendency of reduced production of IgG in the supernatant by purified CD19 + B cells, relative to the control group ( Figure 3E )

These data indicated that supplementary administration of a fermentable fiber has beneficial effects on augmented asthma pathophysiology in obese individuals via SCFAs, and that SCFAs might also be candidates in gut microbiome-targeted therapies in obese asthmatic patients

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