Transdermal estradiol, delivered through patches or gels, bypasses hepatic first-pass metabolism and is associated with meaningfully lower thrombotic risk than oral estrogen formulations [18]
Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD, Croitoru K, Crohns and Colitis Canada Genetic Environmental Microbial Project Research Consortium
Statistical analysis The statistical analyses and figures (Figs
Demonstrating structural similarity with the original reference product is a key requirement for regulatory approval