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Myth vs Fact: GLP1 and Hair Loss Myth: GLP-1 medications directly damage hair follicles

These effects were achieved under reduced activation of noncanonical signaling pathways including receptor internalization and -arrestin recruitment, an initially surprising observation as these have previously been linked to increased GLP-1R responses when measured acutely 10,14,36

This hyperactivity spurs immune disequilibrium and psoriasis progression by magnifying histone H3 acetylation at the IL-17A promoter, which in turn bolsters Th17 and T17 cell differentiation (110)