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Nanoformulations, including nanoparticles, liposomes, micelles, and hydrogels, are designed to target the distinct microenvironment of inflamed joints, which is characterized by leaky vasculature, a mildly acidic pH (~6.0), and elevated reactive oxygen species (ROS), to improve therapeutic efficacy (9)

However, this response was not observed in M1 macrophages, which were able to sustain cell survival and their antimicrobial functions

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