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GST catalyzes the conjugation of cytotoxic agents to glutathione (-glutamyl-cysteinyl-glycine), producing less reactive chemical species

For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

MOTS-c Peptide Structure Source : PubChem PubChem Identifier : CID 146675088 Amino Acid Sequence : H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH Molecular Formula : C101H152N28O22S2 Molecular Weight : 2174.6 g/mol Product Usage This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY