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While traditional sleep aids force sedation by suppressing neural activity and often disrupt natural sleep architecture (particularly REM sleep), DSIP supports the bodys endogenous sleep-regulating systems to promote natural, restorative sleep with proper progression through all sleep stages

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Simultaneously, sleep deprivation was found to change the expression of clock genes and BMAL1/CLOCK heterodimers binding, thus altering clock function

Additionally, gut microbiota regulate tryptophan metabolism to produce indole derivatives and modulate the hosts KP pathway, playing a crucial role in immune homeostasis, neural signaling, and energy metabolism balance