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The complexity of nucleic acids and their types, sizes, and mechanisms of action have made the development of NADs systematically very complex
1 Introduction Globally, knee osteoarthritis (KOA) is one of the most commonly occurring disabling conditions, affecting over 364 million adults (Li et al., 2024), and it is widely recognized as the most prevalent and representative form of osteoarthritis (OA)
This requirement becomes particularly critical during high-intensity exercise when muscle demand for blood volume increases proportionally
The effects of these hormonal disturbances include increased fatty acid release from adipose tissue triglycerides
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