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In some cases, temporarily reducing the dose or slowing the rate of dose escalation may be appropriate

This has remained unchanged for decades [5] and reflects a continued failure in developing effective therapies for bipolar depression [8, 9]

Flegal, K., Carroll, M., Kuczmarski, R

Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study