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Who May Be at Higher Risk for Weight Regain and How to Prepare Patients with type 2 diabetes, polycystic ovary syndrome (PCOS), metabolic syndrome, or strong family history of obesity face higher weight regain risk due to underlying insulin resistance and dysregulated appetite signaling

In the UK and EU, these are included as warnings and precautions in the product information, rather than formal contraindications (unlike in the US, where they appear as boxed warnings and contraindications)

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