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Most calcitonin assessments were below the upper normal limit during the 2-year trial period, and no differences in mean concentrations were observed between liraglutide 2.4/3.0 mg and orlistat by logistic regression (estimated odds ratio for liraglutide 2.4/3.0 mg versus orlistat was 0.5 (95% confidence interval 0.171.6)

This historical context is significant because it positions the industrys compounded GLP-1 expansion as a temporary opportunity that will diminish as branded supply stabilises

References GLP-1 Agonists: Mechanisms to Applications Wilding JPH, Batterham RL, Calanna S, et al