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First, prescription data for newly generated prescription numbers were considered, which include both newly prescribed drugs as well as refills or continuation of existing medications with a new prescription number

This technical difference is a key point in the defenses argument

Classic notions of GLP-1 acting as a meal-stimulated hormone from the distal gut are challenged by data supporting production of GLP-1 in the endocrine pancreas, and by the importance of brain-derived GLP-1 in the control of neural activity

It also explains why oral protocols are sometimes dosed away from large meals or split across the day to manage transit and local contact time rather than to chase a blood-level peak