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doi: 10.1007/s40263-018-0593-6 117 DuringMJCaoLZuzgaDSFrancisJSFitzsimonsHLJiaoXet al

18 Smoking, biofuel smoke-induced oxidative stress and excessive protease production are major factors in COPD pathogenesis that cause alveolar cell death, destruction of the extracellular matrix in the alveolar region and loss of alveolar structure

Child-Pugh A (mild impairment, score 5-6)

Scand J Gastroenterol 31: 665-670, 1996