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Vitamin B12 is important for proper digestion, and a deficiency can lead to digestive issues such as diarrhoea, constipation, and loss of appetite
A landmark 2025 review published in Springer Nature's European Journal of Medical Research confirmed that berberine engages these AMPK-driven pathways consistently across preclinical and clinical studies, making it one of the most mechanistically rich natural compounds for metabolic dysfunction
74 Conversely, extracellular HSP27 has been associated with diabetic complications, including nephropathy and platelet aggregation, emphasizing its complex role in disease progression
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