Moreover, MRI-guided multimodal therapy has shown promising results
As endogenous GLP-1 has a very short half-life, these central actions are likely to be more relevant during therapeutic use of DPP4-resistant GLP-1R analogs, or in post-gastric bypass surgeries, in which GLP-1 equivalent levels, or postprandial GLP-1, respectively, are augmented and sufficient to elicit anorectic responses at these CNS targets
Yaksh,T.L., Kokotos, G., Svensson, C.I., Stephens, D., Kokotos, C.G., Fitzsimmons, B., Hadjipavlou-Litina, D., Hua, X.Y
These conclusions are supported by the observation that the positive inotropic effect of retatrutide was attenuated, in part, by a GIP receptor antagonist, in part by a glucagon receptor antagonist and in part by a GLP-1 receptor antagonist