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The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]

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Concurrently, LPS treatment led to a significant decrease of approximately 19% in SOD activity, a crucial antioxidant enzyme

Monocyte-derived macrophages proliferate in response to hematopoietic growth factors such as macrophage colony-stimulating factor (M-CSF) and accumulate cholesteryl esters, forming foam cells (231234)