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Mol Neurobiol (2017) 54:427191

found that acetaminophen causes concentration-dependent neuronal death in vitro at concentrations that are reached in human plasma during acetaminophen overdose, and are reached in the cerebrospinal fluid of rats for 3 h following doses that are below those required to induce acute hepatic failure in rats

Appl Catal B 219:241248

In a rotenone-induced PD model in rodents, DA4-JC also alleviated motor symptom dysfunctions, protecting dopaminergic neurons mediated through the restoration of mitochondrial function via the Akt/c-Jun N-terminal kinase (JNK) signaling pathway [116]