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Similar warnings regarding acute pancreatitis, including rare necrotising and fatal cases, are already reflected in regulatory product information from the European Medicines Agency (EMA), the US (FDA), and the Australian (TGA) This does not negate the benefits of these therapies when appropriately prescribed, but it reinforces the importance of: careful patient selection ongoing clinical monitoring and avoiding unsupervised or online use without proper medical assessment Particularly relevant as GLP-1based therapies are increasingly sought by midlife women for weight management, often outside structured medical programmes

GLP-1 agonists have become popular treatments for weight loss and type 2 diabetes, and newer studies suggest other health benefits as well

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The maintenance of the adequate renal flow of the blood, by forced alkaline diuresis, might prevent this complication