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ACTG is committed to conducting research that identifies solutions to the comorbidities that most impact people living with HIV and we are encouraged by these results. MASLD and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH), are responsible for a growing proportion of advanced liver disease worldwide

They can include prescription medications, natural herbs, amino acids, vitamins, and other dietary supplements

The predominantly hepatic metabolism of orforglipron does, however, raise the question of whether dose adjustment is needed in hepatic impairment, an issue that was addressed in dedicated hepatic impairment studies during the clinical development program