3bd and Extended Data Fig
Les voies molculaires documentes en recherche prclinique incluent : (1) activation de la synthse d'oxyde nitrique (NO) via la voie L-arginine/eNOS, (2) surexpression transcriptionnelle de VEGF-A et FGF-2 favorisant l'angiogense, (3) modulation du facteur de transcription prcoce Egr-1 impliqu dans la prolifration fibroblastique, (4) interaction avec les rcepteurs 5-HT2A et dopaminergiques dans certains modles comportementaux, (5) stabilisation de la fonction endothliale via modulation de la eNOS et rduction du stress oxydatif (8-OH-dG, MDA)
By inhibiting NNMT and preserving NAD, 5-Amino-1MQ triggers a metabolic shift toward greater energy expenditure
1) Targets Fat Metabolism (AOD 9604) Supports pathways commonly associated with: fat breakdown stubborn fat reduction support lean tissue protection during dieting 2) Supports Energy + Metabolic Flexibility (MOTS-c) Supports: mitochondrial energy production better fuel utilization (carbs + fats) metabolic resilience during stress, dieting, or busy seasons 3) Supports Visceral Fat + Midsection Goals (Tesamorelin) Supports: visceral fat reduction in certain individuals midsection-focused body composition goals metabolic pathway support under provider guidance 4) Supports Recovery + Sleep (Ipamorelin) Supports: deeper, more restorative sleep better recovery between workouts improved consistency (because you feel better while leaning out) In simple terms: AOD + MOTS-c help the metabolism feel on, Tesamorelin supports midsection/visceral fat goals, and Ipamorelin helps you recover and sleep so you can stay consistent
