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DOI: 10.1097/NEN.0b013e3181cb5af4.Oxidative 84

It does this with exceptional potency and a long half-life of approximately 7 days, which enables once-weekly dosing

Quick Answer: Most patients notice reduced appetite within days to weeks of starting semaglutide, while blood sugar improvements begin within 12 weeks, but maximum effects require 45 weeks to reach steady-state drug levels

10.1007/s00125-009-1611-5 25 JamwalS.BlackburnJ