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In fact, one clinical study comparing the same amount of B-12 given orally or under the tongue found they were equally effective at correcting B-12 deficiency over a two-month period

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Importantly, their effects go beyond simple calorie restriction

Involvement of a dysfunctional dopamine-D1/N-methyl-Daspartate- NR1 and Ca2+/Calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine