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It is produced primarily in the liver and is involved in many critical biological functions in the body including metabolism of toxins, immune system function, protection against oxidative cell damage, and recycling of vitamins E and C

This leads to underdiagnosis and mismanagement

Dox treatment induced robust expression of full-length (FL) p21 in both Control and p53 KO cells, which was not further augmented by co-treatment with nutlin-3 (Fig 2A)

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