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Microdose semaglutide and microdose tirzepatide deliver the metabolic benefits of GLP-1 therapy at a fraction of the standard dose

(2017) reported hypomethylation of the imprinted IGF2 gene of the differentially methylated region 2 (DMR2) in the Longissimus dorsi muscle of the restricted offspring

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Accordingly, future research must avoid excessive doses, include fed/fasted states and adequate durations, define metabolic status, and avoid extrapolating hyperlipidemic model results to healthy populations